Root Causes Holistic Health & Medicine

Root Causes Holistic Health & Medicine is a functional and integrative medicine clinic in Fort Myers, Florida.

Clinicians

• Doreen DeStefano, DNP, APRN — founder; integrative and investigative medicine
• Barry Butler, MD — medical director
• Anni Puleo, RN

Regenerative treatments offered

• Stem cell therapy — umbilical cord blood-derived stem cells, offered under the clinic’s “Stem Cell and Exosome Rejuvenation” service
• Exosome therapy — described as vesicles derived from mesenchymal stem cells
• PRP facial

Conditions the practice lists

The stem cell and exosome page lists osteoarthritis, cartilage, tendon and muscle injuries, and skin rejuvenation and wrinkles. The website also lists spinal cord injury, rheumatoid arthritis, lupus, multiple sclerosis, stroke, traumatic brain injury, Parkinson’s disease, heart disease, chronic Lyme disease symptoms, COVID-19 recovery, liver fibrosis and macular degeneration.

What to know before you call

• Office hours are Monday, Wednesday and Friday, with evenings by appointment.
• The clinic also offers hyperbaric oxygen therapy, IV therapy, bioidentical hormone therapy and integrative oncology services.
• Prices and insurance policies are not published.
• The site names the Metabolic Terrain Institute of Health as a “next location.”

RPG verification notes

• Clinician credentials listed on the About page
• Website shows an FDA disclaimer stating its statements have not been evaluated by the FDA
• No clinician named for stem cell or exosome procedures
• Prices not published

Last verified by Regen Provider Guide: October 2026. Confirm treatment details, candidacy, insurance coverage and costs directly with the practice. RPG makes no claim about the effectiveness of any treatment.